ASSOCIATION BETWEEN BLOOD DONATION FREQUENCY, ANTIOXIDANT ENZYMES AND LIPID PEROXIDATION

  • M Mehrabani 1) Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical S
  • m Djalali 1) Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical S
  • M Sadeghi 1) Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical S
  • B Hajibeigi 2) Iranian Blood Transfusion Organization Research Center, Tehran, Iran
  • H Zeraati 3) Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medic
  • F Fatehi 1) Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical S
  • M Chamari 1) Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical S
Keywords: superoxide dismutase,

Abstract

Iron is a pro-oxidant cofactor that may belinked to atherosclerosis progression. Free iron catalyzes the generation of free radicals and free radicals promote the oxidation of lipids. Reduction of body ironstores secondary to blood donation has been hypothesized toreduce lipid peroxidation. The aim of this study was to evaluate the association between blood donation and antioxidant enzymes and lipid peroxidation product malondialdehyde (MDA). We investigated hemoglobin (Hb), serum ferritin, MDA level, glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities in the whole blood of 150 male volunteer blood donors aged from 30 to 60 years attending Tehran Blood Transfusion Center. Subjects were divided into 5 groups according to the frequency of blood donation per year. With increasing the number of blood donation in a year, the body iron stores, GPX activities and serum MDA were significantly reduced (P < 0.05) but SOD was significantly increased (P < 0.05). High-frequency blood donors had evidenceof decreased body iron stores, decreased lipid peroxidation and enhanced activity of antioxidant enzymes when compared with low-frequencydonors

How to Cite
1.
Mehrabani M, Djalali m, Sadeghi M, Hajibeigi B, Zeraati H, Fatehi F, Chamari M. ASSOCIATION BETWEEN BLOOD DONATION FREQUENCY, ANTIOXIDANT ENZYMES AND LIPID PEROXIDATION . Acta Med Iran. 46(5):361-366.
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