Acta Medica Iranica 2008. 46(5):361-366.

ASSOCIATION BETWEEN BLOOD DONATION FREQUENCY, ANTIOXIDANT ENZYMES AND LIPID PEROXIDATION
M Mehrabani, m Djalali, M Sadeghi, B Hajibeigi, H Zeraati, F Fatehi, M Chamari

Abstract


Iron is a pro-oxidant cofactor that may belinked to atherosclerosis progression. Free iron catalyzes the generation of free radicals and free radicals promote the oxidation of lipids. Reduction of body ironstores secondary to blood donation has been hypothesized toreduce lipid peroxidation. The aim of this study was to evaluate the association between blood donation and antioxidant enzymes and lipid peroxidation product malondialdehyde (MDA). We investigated hemoglobin (Hb), serum ferritin, MDA level, glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities in the whole blood of 150 male volunteer blood donors aged from 30 to 60 years attending Tehran Blood Transfusion Center. Subjects were divided into 5 groups according to the frequency of blood donation per year. With increasing the number of blood donation in a year, the body iron stores, GPX activities and serum MDA were significantly reduced (P < 0.05) but SOD was significantly increased (P < 0.05). High-frequency blood donors had evidenceof decreased body iron stores, decreased lipid peroxidation and enhanced activity of antioxidant enzymes when compared with low-frequencydonors


Keywords


superoxide dismutase,

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.