A Case Report of Cyclic Neutropenia Associated with Pyoderma Gangrenosum

  • Hossain Jabbari Infectious Diseases Department, Tehran University of Medical Sciences, Tehran, Iran. AND Digestive Diseases Research Institute (DDRI), Tehran University of Medical Sciences, Tehran, Iran. AND Iranain Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Payvarmehr Iranain Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.
  • SeyedAhmad SeyedAlinaghi Iranain Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.
  • Neda Roosta Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Keywords: Cyclic neutropenia, Pyoderma gangrenosum

Abstract

We present a 24-year-old female referred with non-healing wound of a few days duration on anterior aspect of her right foreleg. Biopsy of the wound was reported to be pyoderma gangrenosum on pathologic report. Further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia. Treatment with granulocyte colony-stimulating factor (G-CSF) resulted in patient's neutrophil counts correction and dramatic improvement in healing of her lower extremity wound.

References

Lange RD, Jones JB. Cyclic neutropenia. Review of clinical manifestations and management. Am J Pediatr Hematol Oncol 1981;3(4):363-7.

Lubitz PA, Dower N, Krol AL. Cyclic neutropenia: an unusual disorder of granulopoiesis effectively treated with recombinant granulocyte colony-stimulating factor. Pediatr Dermatol 2001;18(5):426-32.

Dale DC, Hammond WP. Cyclic neutropenia: a clinical review. Blood Rev 1988;2(3):178-85.

Wright DG, Dale DC, Fauci AS, Wolff SM. Human cyclic neutropenia: clinical review and long-term follow-up of patients. Medicine (Baltimore) 1981;60(1):1-13.

Cohen PR. Neutrophilic dermatoses: a review of current treatment options. Am J Clin Dermatol 2009;10(5):301-12.

Collins RD. Differential Diagnosis in Primary Care. Philadelphia, PA: Lippincott Williams and Wilkins; 2007.

Reichrath J, Bens G, Bonowitz A, Tilgen W. Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients. J Am Acad Dermatol 2005;53(2):273-83.

How to Cite
1.
Jabbari H, Payvarmehr F, SeyedAlinaghi S, Roosta N. A Case Report of Cyclic Neutropenia Associated with Pyoderma Gangrenosum. Acta Med Iran. 49(11):763-765.
Section
Articles