Evaluation of febrile neutropenia in patients undergoing hematopoietic stem cell transplantation.

  • Shahideh Amini Department of Clinical Pharmacy, Faculty of Pharmacy,Tehran University of Medical Sciences, Tehran, Iran.
  • Molouk Hadjibabaie Research Center for Rational Use of Drug and Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Jahangard-Rafsanjani Department of Clinical Pharmacy, Faculty of Pharmacy,Tehran University of Medical Sciences, Tehran, Iran.
  • Asieh Ashuri Department of Hematology Oncology, Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Hassan Torkamandi Department of Pharmaceutical Care, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ardeshir Ghavamzadeh Department of Hematology Oncology, Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Antibiotic therapy, HSCT, Neutropenic fever

Abstract

The aim of this study was to determine the incidence and causes of fever as a major problem contributing to transplantation related mortality among patients undergoing hematopoietic stem cell transplantation (HSCT) and evaluation of antibiotic use, according to reliable guidelines.We retrospectively reviewed hospital records of 195 adult patients who underwent HSCT between 2009-2011 at hematology-oncology and bone marrow transplantation research center. Baseline information and also data related to fever and neutropenia, patient's outcomes, duration of hospitalization and antibiotic use pattern were documented.A total of 195 patients were analyzed and a total of 268 febrile episodes in 180 patients were recorded (mean 1.5 episodes per patient). About 222 episodes (82%) were associated with neutropenia which one-fourth of them were without any documented infection sources. Microbiologic documents showed that the relative frequencies of gram positive and gram negative bacteria were 62.5% and 37.5%, respectively. The hospital stay duration was directly related to the numbers of fever episodes (P<0.0001).The rate of febrile episodes in autologous stem cell transplantation was significantly higher compared to allogeneic type (P<0.05).It is necessary to determine not only the local profile of microbiologic pattern, but also antibiotic sensitivities in febrile neutropenic patients following hematopoietic stem cell transplantation, and reassess response to antibiotic treatment to establish any necessity for modifications to treatment guidelines in order to prevent any fatal complications from infection.

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How to Cite
1.
Amini S, Hadjibabaie M, Jahangard-Rafsanjani Z, Ashuri A, Torkamandi H, Ghavamzadeh A. Evaluation of febrile neutropenia in patients undergoing hematopoietic stem cell transplantation. Acta Med Iran. 52(1):38-42.
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