Systemic Amyloidosis in a Teenage Boy With Inflammatory Bowel Disease
AbstractSystemic amyloidosis is a very rare complication of inflammatory bowel disease (IBD). The reported cases of secondary amyloidosis in children with IBD are much fewer than those reported in adults. Herein, a teenage boy with Crohn’s disease is presented who developed nephrotic syndrome due to renal involvement secondary to amyloidosis, whereas the patient was under treatment with corticosteroid and 6-mercaptopurine. To our best knowledge, this is the first reported case of secondary amyloidosis in a teenage Iranian boy with Crohn’s disease.
Serra L, Oller B, Manosa M, Naves JE, Zabana Y, Cabré E, et al. Systemic amyloidosis in inflammatory bowel disease. J Crohns Colitis 2010;4:269-74.
Markowitzj KE, Simpser E, Aiges H, Daum F.Amyloidosis in children with inflammatory bowel disease. J Pediatr Gastroentral Nutr 1989;8:447-53.
Katsanos KH, Tsianos EV. The kidneys in inflammatory bowel disease. Ann Gastroenterol 2002;15:41-52
Dhanwan R, Diamond HS. AA (Inflammatory) Amyloidosis. (Accessed May 2016, 20, at http://emedicine:Medscape.com/article/33559-overview).
Wester AL, Vatn MH, Fausa O. Secondary amyloidosis in inflammatory bowel disease. Inflamm Bowel Dis 2001;7:295-300
UsluN, Yüce A, Damir H, Saltik-Temizel IN, Usta Y, Yilmaz E, et al. The association of inflammatory bowel disease and Mediterranean Fever gene (MEFV) mutations in Turkish children. Dig Dis Sci 2010;55:3488-94.
Yildirim B, Tuncer C, Kan D, Tunc B, Demirag MD, Ferda Percın E, et al. MEFV gene mutations and its impact on the clinical course in ulcerative colitis patients. Rheumatal Int 2011;31:859-64
Vahedi H, Meratsh, Momtahensh, Olfati G, Kazzazi AS, Tabrizian T, et al. Epidemiologic characteristics of 500 patients with Inflammatory bowel disease in Iran studied from 2004 through 2007. Arch Iran Med 2009;12:454-60.