The Relation between Diverse Phenotypes of PCOS with Clinical Manifestations, Anthropometric Indices and Metabolic Characteristics

  • Seyedeh Hajar Shahrami Department of Obstetrics and Gynecology, Reproductive Health Research Center, Guilan University of Medical Sciences, Iran.
  • Zahra Abbasi Ranjbar Department of Endocrinology and Metabolism, Reproductive Health Research Center, Guilan University of Medical Sciences, Iran
  • Forozan Milani Department of Obstetrics and Gynecology, Reproductive Health Research Center, Guilan University of Medical Sciences, Iran.
  • Ehsan Kezem-Nejad Department of Statistically, Guilan University of Medical Sciences, Iran.
  • Afagh Hassanzadeh Rad Pediatric Growth Disorders Research Center, Guilan University of Medical Sciences, Iran.
  • Seyedeh Fatemeh Dalil Heirat Reproductive Health Research Center, Guilan University of Medical Sciences, Iran.
Keywords: PCOS, Hyperandrogenism, Rotterdam criteria, Laboratory, Phenotypes

Abstract

Critical issue regarding to variation of findings based on different phenotypes led investigators to define whether they are distinct features or overlapping ones. Therefore, we aimed to investigate the association between diverse phenotypes of PCOS (Poly Cystic Ovary Syndrome) with clinical manifestations, anthropometric indices, and metabolic characteristics. This was a descriptive cross-sectional study conducted in 15-39 years old women with PCOS referred to infertility clinics in the north part of Iran, Rasht during 2010-2011. Data were gathered through an interview by a form consisted of demographic characteristics, laboratory findings, ovarian volume and anthropometric indices. A total of 214 patients consisted of 161 PCOS (cases) and 53 normal women (controls) participated in this study. The most prevalent phenotype in PCOS population was IM/PCO/HA (54%), followed by IM/HA (28%) and IM/PCO (13%). PCO/HA was present only in 6 PCOS patients (5%). PCOS patients were significantly younger than controls (P=0.07). Results showed that increased ovarian volume were higher in PCOS group in comparison with controls and IM/PCO/HA, and IM/PCO had respectively the largest ovarian volumes. Also, a significant relation was observed based on Cholesterol, 17OHP, LH, TG, 2hpp, and LH/FSH between patients with PCOS and control groups. There were significant differences in demographic, anthropometric, hormonal and ultrasound findings between PCOS and controls. Therefore, it seems that classification of the characteristics of each phenotype could offer an appropriate guide for screening risks of PCOS and may facilitate performing most favorable treatment for these complications.

References

Fauser BC, Tarlatzis BC, Robar RW, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 2012;97(1):28-38.

Castelo-Branco C, Steinvarcel F, Osorio A, et al. Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. Gynecol Endocrinol 2010;26(10):736-42.

Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19(1):41-7.

Gambineri A, Pelusi C, Vicennati V, et al. Obesity and the polycystic ovary syndrome. Int J Obes Rel Metab Disord 2002;26(7):883-96.

Glueck CJ, Goldenberg N, Wang P, et al. Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy. Hum Reprod 2004;19(3):510-21.

Palomba S, Falbo A, Russo T, et al. Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes. Fertil Steril 2010;94(5):1805-11.

Azziz R. Controversy in clinical endocrinology: diagnosis of polycysticovarian syndrome: the Rotterdam criteria are premature. J Clin Endocrinol Metab 2006;91(3):781-5.

Franks S. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defence of the Rotterdam criteria. J Clin Endocrinol Metab2006;91(3):786-9.

Chang WY, Knochenhauer ES, Bartolucci AA, et al. Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups. Fertil Steril 2005;83(6):1717-23.

Welt CK, Gudmundsson JA, Arason G, et al. Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features. J Clin Endocrinol Metab 2006; 91(12):4842-8.

Pehlivanov B, Orbetzova M. Characteristics of different phenotypes of polycystic ovary syndrome in a Bulgarian population. Gynecol Endocrinol 2007;23(10): 604-9.

Yilmaz M, Isaoglu U, Delibas IB, et al. Anthropometric, clinical and laboratory comparison of four phenotypes of polycystic ovary syndrome based on Rotterdam criteria. J Obstet Gynaecol Res 2011;37(8):1020-6.

Hassa H, Tanir HM, Yildiz Z. Comparison of clinical and laboratory characteristics of cases with polycystic ovarian syndrome based on Rotterdam's criteria and women whose only clinical signs are oligo/anovulation or hirsutism. Arch Gynecol Obstet 2006;274(4):227-32.

Katsikis J, Karkanaki A, Misichronis G, et al. Phenotypicexpression, body mass index and insulin resistance in relation to LH levels in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2011;156(2):181-5.

Madani T, Hosseini R, Ramezanali F, et al. Prevalence of prediabetes state is not equal in all phenotypes of polycystic ovary syndrome. Proceedings of the 15th European Congress of Endocrinology: 2013 Apr-May 27-01, Copenhagen, Denmark.

Sung YA. Polycystic Ovary Syndrome in Korean Women: Clinical Characteristics and Diagnostic Criteria. Endocrinol Metab 2011;26(3):203-7.

Published
2016-03-12
How to Cite
1.
Shahrami SH, Abbasi Ranjbar Z, Milani F, Kezem-Nejad E, Hassanzadeh Rad A, Dalil Heirat SF. The Relation between Diverse Phenotypes of PCOS with Clinical Manifestations, Anthropometric Indices and Metabolic Characteristics. Acta Med Iran. 54(2):134-139.
Section
Original Article(s)