Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study

  • Alireza Heidari-Bakavoli Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Seyed Mahdi Hassanian Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. and Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. and Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Amir Avan Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. and Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mojtaba Shafiee Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Afsane Bahrami Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
  • Maryam Tayefi Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Samaneh Khakpouri Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Parvin Zamani Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohsen Moohebati Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mahmoud Ebrahimi Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Farzad Rahmani Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Habibollah Esmaeili Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohsen Nematy Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. and Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohammad Safarian Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Gordon A. Ferns Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
  • Mahmoud Reza Azarpajouh Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohammad Reza Parizadeh Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. and Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Majid Ghayour-Mobarhan Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran and .Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Keywords: Hypertriglyceridemia, White blood cell count, Cardiovascular disease

Abstract

Hypertriglyceridemia is a common form of dyslipidemia and is associated with several comorbidities, such as increased risk of pancreatitis and cardiovascular diseases (CVD). The white blood cell (WBC) count is a non-specific inflammatory marker associated with a wide variety of diseases such as diabetes, hypertension, and atherosclerotic cardiovascular disease. The objective of this study was to perform a gender-stratified examination of the association between hypertriglyceridemia and hematological parameters in a large sample of Iranian population. The triglyceride (TG) levels and hematological parameters were measured in 9,780 participants (40% males and 60% females) aged 35-65 years, enrolled in a population-based cohort (MASHAD) study in northeastern Iran. Participants were stratified into three groups based on the definition of hypertriglyceridemia: TG<150 mg/dl (n=6521), TG=150-199 mg/dl (n=1597), and TG≥200 mg/dl (n=1662). A complete blood count (CBC) was obtained for all the subjects. The mean WBC count increased with increasing severity of hypertriglyceridemia among both men and women. Participants with high and very high TG levels had significantly higher WBC count, RBC count, platelet count, hemoglobin, hematocrit, and mean corpuscular hemoglobin concentration and significantly lower RDW. After performing multivariate logistic regression, WBC count and RDW were independently related to hypertriglyceridemia. In conclusion, hypertriglyceridemia is associated with elevated WBC count which may partly explain the observed association between hypertriglyceridemia and CVD.

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Published
2019-01-12
How to Cite
1.
Heidari-Bakavoli A, Hassanian SM, Avan A, Shafiee M, Bahrami A, Tayefi M, Khakpouri S, Zamani P, Moohebati M, Ebrahimi M, Rahmani F, Esmaeili H, Nematy M, Safarian M, Ferns GA, Azarpajouh MR, Parizadeh MR, Ghayour-Mobarhan M. Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study. Acta Med Iran. 56(10):645-652.
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Articles