Clinicoepidemiological Features of 82 Cases of Bullous Pemphigoid in Tehran, Iran
Bullous Pemphigoid is a chronic immunobullous disease, characterized by subepidermal bulla on the skin and mucosa. The purpose of the present study was to investigate the clinicoepidemiological features of bullous pemphigoid in Iranian patients. In this retrospective descriptive study, we reviewed 82 bullous pemphigoid patients within 2014-2016. The mean age of the patients was 67.13 years (range between 25 and 97) including 32(39.1%) males and 50(60.9%) females. Mucosal involvement was positive in 33(40.2%) of the patients, and oral mucosa was most commonly involved. Head and neck area were involved in 43 (52.4%) of the patients. Clinical and epidemiological characteristics of bullous pemphigoid are different in different regions of the world.
Langan S, Smeeth L, Hubbard R, Fleming K, Smith C, West J. Bullous pemphigoid and pemphigus vulgaris—incidence and mortality in the UK: population based cohort study. Bmj. 2008;337:a180.
Junga M, Kippesb W, Messer G, Zillikens D, Rzany B. Increased risk of bullous pemphigoid in male and very old patients: a population-based study on incidence. Journal of the American Academy of Dermatology. 1999;41(2):266-8.
Schmidt E, Della Torre R, Borradori L. Clinical features and practical diagnosis of bullous pemphigoid. Immunology and allergy clinics of North America. 2012;32(2):217-32.
Marazza G, Pham HC, Scharer L, Pedrazzetti PP, Hunziker T, Trueb RM, et al. Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study. The British journal of dermatology. 2009;161(4):861-8.
Colbert RL, Allen DM, Eastwood D, Fairley JA. Mortality rate of bullous pemphigoid in a US medical center. The Journal of investigative dermatology. 2004;122(5):1091-5.
Korman NJ. Bullous pemphigoid. The latest in diagnosis, prognosis, and therapy. Archives of dermatology. 1998;134(9):1137-41.
Daneshpazhooh M, Chams-Davatchi C, Payandemehr P, Nassiri S, Valikhani M, Safai-Naraghi Z. Spectrum of autoimmune bullous diseases in Iran: a 10-year review. International journal of dermatology. 2012;51(1):35-41.
Esmaili N, Hallaji Z, Soori T, Chams Davatchi C. Bullous pemphigoid in Iranian patients: a descriptive study on 122 cases. Acta medica Iranica. 2012;50(5):335-8.
Ghiasi M, Daneshpazhooh M, Ismonov M, Chams-Davatchi C. Evaluation of Autoimmune Bullous Diseases in Elderly Patients in Iran: A 10-Year Retrospective Study. Skinmed. 2017;15(3):175.
Jowkar F, Sadat Sadati M, Tavana S, Agah MA. Epidemiology of autoimmune bullous diseases and therapeutic modalities during a 10 year period in Iran. Acta Dermatovenerologica Croatica. 2014;22(4):246-.
PEIYING J, CHANGGENG S, GANYUN Y. Chronic bullous dermatoses in China. International journal of dermatology. 1993;32(2):89-92.
Zaraa I, Kerkeni N, Ishak F, Zribi H, El Euch D, Mokni M, et al. Spectrum of autoimmune blistering dermatoses in Tunisia: an 11‐year study and a review of the literature. International journal of dermatology. 2011;50(8):939-44.
Schmidt E, Zillikens D. Pemphigoid diseases. Lancet (London, England). 2013;381(9863):320-32.
Chang Y, Liu H, Wong C. Bullous pemphigoid—a report of 86 cases from Taiwan. Clinical and experimental dermatology. 1996;21(1):20-2.
Bernard P, Vaillant L, Labeille B, Bedane C, Arbeille B, Denoeux JP, et al. Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Bullous Diseases French Study Group. Archives of dermatology. 1995;131(1):48-52.
Rzany B, Partscht K, Jung M, Kippes W, Mecking D, Baima B, et al. Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old age. Archives of dermatology. 2002;138(7):903-8.
Nanda A, Al-Saeid K, Al-Sabah H, Dvorak R, Alsaleh QA. Clinicoepidemiological features and course of 43 cases of bullous pemphigoid in Kuwait. Clinical and experimental dermatology. 2006;31(3):339-42.
Banihashemi M, Zabolinejad N, Vahabi S, Razavi HS. Survey of bullous pemphigoid disease in northern Iran. International journal of dermatology. 2015;54(11):1246-9.