The Correlation of Irisin Levels and Some Trace Element as a Potential Mark Diagnosis of Gestational Diabetes Mellitus.

  • Majid Jawad AL-Ghazali Department of Chemistry, College of Sciences, Kufa University, Kufa, Iraq. http://orcid.org/0000-0001-7048-7879
  • Hanaa Addai Ali Department of Chemistry, College of Sciences, Kufa University, Kufa, Iraq.
  • Mohauman Mohammad AL-Rufaie Department of Chemistry, College of Sciences, Kufa University, Kufa, Iraq.
  • Rawaa Adday Ali Department of Microbiology, Collage of Veterinary Medicine AL-Qasim, Green University, Kufa, Iraq.
Keywords: Gestational diabetes mellitus, Irisin, Trace elements, Glycemic

Abstract

The objective of this project was investigating and comparing changes of serum irisin, and trace levels of the elements (Zn, Cu, Mg) in pregnant women with gestational diabetes mellitus GDM in addition to wholesome pregnant group, examining the correlation among (Zn, Cu, Mg) levels and irisin insulin impedance in GDM pregnant women. Sixty GDM pregnant women and thirty wholesome pregnant women were examined. The pair groups were matched for age, and maternal serum irisin. Insulin levels and gestational age were calculated by the assay for enzyme-linked immune sorbent kit at gestation at 24-28 weeks. The confederation between clinical and biochemical parameters and maternal serum irisin levels were predestined. Serum levels of glucose, body mass index, insulin, OGTT, HOMA IR, HOMAβ, HbA1c, Hb%, irisin, Zn, Cu and Mg were investigated and analyzed for the examined collection as well as control samples. Pregnant women with GDM disease had noteworthy rising fast blood glucose FBG (P=0.004), first-hour OGTT glucose (P=0.001), second-hour OGTT glucose (P=0.001), fasting insulin FI (P=0.001) levels, HOMA IR (P=0.001), HOMAβ (P=0.001), HbA1C (P=0.001), Hb% (P=0.017), as contrasted to healthy women. Levels of irisin serum were significantly minimizing (P=0.001) in women, and sequentially more advanced GDM (mean±SD=71.65±8.03) than healthy pregnant controls (mean±SD 136.54±22.56). Analyses among irisin levels of anthropometric and biochemical values in gestational diabetes patients disclosed that none of the scrupulousness values were remediated with serum irisin level. His present outcomes indicate that the levels of serum irisin might be presented as an incoming GDM marker with decreased irisin levels being GDM symptomatic.

References

American Diabetes Association. Gestational diabetes mellitus. Diabetes Care. 2004, 27 (1), 88–90.

Metzger BE, Coustan DR. The Organizing Committee: summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care. 1998, 21 (2), 161–167

American Diabetes Association, 2014). American Diabetes Association. (2014). What is gestational diabetes? Retrieved from http://www.diabetes.org/diabetes-basics/gestational/what-is-gestational-diabetes.html

.Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA. Longitudinal changes

in insulin release and insulin resistance in nonobese pregnant women. Am J Obstet

Gynecol 1991;165:1667-1672.

Vohr BR, Boney CM. Gestational diabetes: the forerunner for the development of

maternal and childhood obesity and metabolic syndrome? J Matern Fetal Neonatal

Med 2008;21:149-157.

Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of

fetal growth restriction and preeclampsia. Am J Obstet Gynecol 2006;195:40-49

Catalano PM, Kirwan JP, Haugel-de Mouzon S, King J. Gestational diabetes and insulin resistance: r,ole in shortand long-term implications for mother and fetus. J Nutr 2003;133:1674S–83S.

Lain KY, Catalano PM. Factors that affect maternal insulin resistance and modify

fetal growth and body composition. Metab Syndr Relat Disord 2006;4:91-100.

Briana DD, Malamitsi-Puchner A. Reviews: adipocytokines in normal and

complicated pregnancies. Reprod Sci 2009;16:921-37

Pedersen BK, Febbraio M.A. Muscles exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 2012;8:457–65.

Bostro¨m P, Wu J, Jedrychowski MP, et al. PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463–8.

Schumacher MA, Chinnam N, Ohashi T, et al. The structure of irisin reveals a novel intersubunit b-sheet fibronectin (FNIII) dimer; implications for receptor activation. J Biol Chem 2013;288: 33738–44

.Aydin S. Three new players in energy regulation: preptin, adropin and irisin. Peptides. 2014, 56, 94–110.

Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-alpha-dependent myokine that drives brown- fat-like development of white fat and thermogenesis. Nature 2012;481:463–8.

Hojlund K, Bostrom P. Irisin in obesity and type 2 diabetes. J Diabetes Complications 2013;27:303–4.

Pedersen BK, Febbraio M.A.. Muscles exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 2012;8:457–65.

Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, et al. Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complications 2013;27:365–9.

Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, et al. Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 2013;100:96–101.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA,

Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti

S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that

drives brown-fat-like development of white fat and thermogenesis. Nature

;481:463-468.

Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F,

Ricart W, Fernández-Real JM. Irisin is expressed and produced by human muscle

and adipose tissue in association with obesity and insulin resistance. J Clin

Endocrinol Metab 2013;98:E769-E778.

Zhang C, Ding Z, Lv G, Li J, Zhou P, Zhang J. Lower irisin level in patients with

type 2 diabetes mellitus: A case-control study and meta-analysis. J Diabetes 2014

Dec 15 [Epub ahead of print].

Park KH, Zaichenko L, Brinkoetter M, Thakkar B, Sahin-Efe A, Joung KE,

Tsoukas MA, Geladari EV, Huh JY, Dincer F, Davis CR, Crowell JA, Mantzoros

CS. Circulating irisin in relation to insulin resistance and the metabolic syndrome.

J Clin Endocrinol Metab 2013;98:4899-4907.

Polyzos SA, Kountouras J, Shields K, Mantzoros CS. Irisin: a renaissance in

metabolism? Metabolism 2013;62:1037-1044.

Garcés MF, Peralta JJ, Ruiz-Linares CE, Lozano AR, Poveda NE, Torres-Sierra

AL, Eslava-Schmalbach JH, Alzate JP, Sánchez AY, Sanchez E, Angel-Müller E,

Ruíz-Parra AI, Diéguez C, Nogueiras R, Caminos JE. Irisin levels during

pregnancy and changes associated with the development of preeclampsia. J Clin

Endocrinol Metab 2014;99:2113-2119.

Metzger BE, Gabbe SG, Persson B, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010;33:676–82

Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–19

Fadl HE, Östlund IKM, Magnuson AFK, Hanson USB. Maternal and neonatal outcomes and time trends of gestational diabetes mellitus in Sweden from 1991 to 2003. Diabet Med 2010;27:436–41.

Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes. Diabet Care 2002;25:1862–8.

Shah BR, Retnakaran R, Booth GL. Increased risk of cardiovascular disease in young women following gestational diabetes mellitus. Diabet Care 2008;31:1668–9

Bao W, Baecker A, Song Y, Kiely M, Liu S, Zhang C. Adipokine levels during the

first or early second trimester of pregnancy and subsequent risk of gestational diabetes

mellitus: A systematic review. Metabolism 2015; 64:756-64

Lain KY, Catalano PM. Factors that affect maternal insulin resistance and modify fetal growth and body composition. Metab Syndr Relat Disord 2006;4:91-100.

Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA. Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women. Am J Obstet Gynecol 1991;165:1667-1672.

Vohr BR, Boney CM. Gestational diabetes: the forerunner for the development of maternal and childhood obesity and metabolic syndrome? J Matern Fetal Neonatal Med 2008;21:149-157.

Briana DD, Malamitsi-Puchner A. Reviews: adipocytokines in normal and complicated pregnancies. Reprod Sci 2009;16:921-37

Yuksel MA, Oncul M, Tuten A, et al. Maternal serum and fetal cord blood irisin levels in gestational diabetes mellitus. Diabetes Res Clin Pract 2014;104:171–175

Kuzmicki M, Telejko B, Lipinska D, Pliszka J, Szamatowicz M, et al. (2014) Serum irisin concentration in women with gestational diabetes. Gynecol Endocrinol 30: 636-639

Aydin S, Kuloglu T, Aydin S (2013) Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus. Peptides 47: 66-70

Ebert T, Stepan H, Schrey S, et al. Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery. Cytokine 2014;652:153–8.

Correa A, Gilboa SM, Besser LM, Botto LD, Moore CA, Hobbs CA, et al. Diabetes mellitus and birth defects. Am J Obst Gynecol. 2008;199:2371-8

Tamas G, Kerenyi Z. Gestational diabetes: current aspects on athogenesis and treatment. Exp Clin Endocrinol Diabetes. 2001;109(Suppl 2):S400-11.

Lupo VR, Stys SJ. Recurrence of gestational diabetes in subsequent pregnancies. In: Weiss PM, Coustan DR, editors. Gestational Diabetes. Vienna, Austria: Springer-Verlag; 1988. p. 123-6.

Rice GE, Illanes SE, Mitchell MD. Gestational diabetes mellitus: a positive predictor of type 2 diabetes? Int J Endocrinol. 2012;2012:721653.

Yuksel MA, Oncul M, Tuten A, Imamoglu M, Acikgoz AS, et al. (2014) Maternal serum and fetal cord blood irisin levels in gestational diabetes mellitus. Diabetes Res Clin Pract 104: 171-175.

Kuzmicki M, Telejko B, Lipinska D, Pliszka J, Szamatowicz M, et al. (2014) Serum irisin concentration in women with gestational diabetes. Gynecol Endocrinol 30: 636-639

Piya MK, Harte AL, Sivakumar K, et al. The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers and gestational diabetes. Am J Physiol Endocrinol Metab 2014;306:E512–E518

Huh JY, Panagiotou G, Mougios V, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012;61: 1725–38

Ebert T, Stepan H, Schrey S, et al. Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery. Cytokine 2014;652:153–8.

. 48. Hee Park K, Zaichenko L, Brinkoetter M, et al. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab 2013;98:4899–907

Piya MK, Harte AL, Sivakumar K, et al. The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers and gestational diabetes. Am J Physiol Endocrinol Metab 2014;306:E512–E518

Choi YK, Kim MK, Bae KH, et al. Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 2013;100:96–101.

Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Med Biol. 2011;25(3):149-53..

Fadia Mahmoud , Habib Abul , Ali Dashti, Waleed Al-Jassar , Alexander Omu, Trace elements and cell-mediated immunity in gestational and pre-gestational diabetes mellitus at third trimester of pregnancy. Acta Medica Academica 2012;41(2):175-185

Abul HT, Mahmoud FF, El-Rayes SK, Haines DD, Omu A. Potential aetiological involvement of Zn++, Cu++, Se++ and Mg++ in pre-eclamptic and hypertensive parturient women in Kuwait. Trace Elements and Electrolytes. 2001;18(1):20-5.

Abul H, Mahmoud F, Haines D, Mannazhath N. Pregnancy-Associated Relationships Between Serum Content of Cu2+, Mg2+, Zn2+, Se2+ and Peripheral Blood Lymphocyte Sub-populations in Kuwaiti Women. Trace Elements and Electrolytes. 2004;21(3):168-73.

Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnes Res. 2006 Sep;19(3):180-9.

König D, Weinstock C, Keul J, Northoff H, Berg A. Zinc, iron, and magnesium status in athletes- -influence on the regulation of exercise-induced stress and immune function. Exerc Immunol Rev. 1998;4:2-21.

Magri J, Sammut M, Savon C. lead and other metals in gestational hypertension. Int J Gynaecol Obstet 2003; 83: 29-36.

Published
2019-02-13
How to Cite
1.
AL-Ghazali MJ, Addai Ali H, Mohammad AL-Rufaie M, Adday Ali R. The Correlation of Irisin Levels and Some Trace Element as a Potential Mark Diagnosis of Gestational Diabetes Mellitus. Acta Med Iran. 57(1):42-50.
Section
Articles