Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 60 9 2022 11 08 599 603 Shahin Koomanaee Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Setila Dalili Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Seyyedeh Azade Hoseini Nouri Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Seyedeh Zohreh Jalali Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Manijeh Tabrizi Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Ghazaleh Aldaghi Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Afagh Hassanzadeh Rad Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran 2022 04 26 2022 06 18 Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder with homozygous or heterozygous mutations in one of the five following genes (ORC1, ORC4, ORC6, CDT1, and CDC6). This syndrome is characterized by the triad of short stature (pre/postnatal), microtia, and patella hypoplasia/aplasia. Special features included microcephaly, microstomia, full lips, micrognathia, narrow convex, and high nasal bridge nose. Also, it may be accompanied by feeding problems, skeletal disorders, urogenital or respiratory anomalies, and intelligence disorders. This case report describes the first Persian MGS accompanied by neonatal seizure, mental retardation, and attention deficit hyperactivity disorder. https://acta.tums.ac.ir/index.php/acta/article/view/10123