Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 64 02 2026 04 03 10986 10986 Ramesh Omranipour 1. Breast Disease Research Center, Cancer Institute, Tehran university of Medical Sciences, Tehran, Iran. 2. Department of Surgical Oncology, Cancer Institute, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran. Negar Mashoori Department of Surgery, Imam Khomeini hospital, Tehran university of Medical Sciences, Tehran, Iran Sadaf Alipour Tehran University of Medical Sciences Azin Saberi Department of Surgery, Arash Women's Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2024 03 08 2025 02 10 Corticosteroids, generally prescribed at high doses, have been used with good results in the treatment of idiopathic granulomatous mastitis (IGM). However, side effects of steroids are a serious concern, and prescribing lower doses sound safer if they provide similar efficacy. Thus, this study was performed to investigate the effect of moderate-dose versus high-dose prednisolone on IGM. Medical records of IGM patients were evaluated retrospectively. Patients who received prednisolone were classified as the moderate-dose group (MDG, <25 mg/day) and the high-dose group (HDG, ≥25 mg/day); their response and recurrence rates were compared. Among 108 patients, 82.5% in HDG and 85.3% in MDG responded to treatment (P=0.7). Total recurrence was 21.7% and 22% in HDG and MDG, respectively (P=0.984). Moderate doses of corticosteroids may be used to treat IGM patients without decreasing the treatment efficacy. Prospective randomized trials are necessary to further clarify this issue. https://acta.tums.ac.ir/index.php/acta/article/view/10986 https://acta.tums.ac.ir/index.php/acta/article/download/10986/6018