Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 61 9 2024 03 16 578 581 Saman Sheikhhosseini Department of Anesthesiology and Pain, Amir A’lam Hospital, Tehran University of Medical Sciences, Tehran, Iran Nader Ali Nazemian Yazdi Department of Anesthesiology and Pain Medicine, Amir A’lam Hospital, Tehran University of Medical Sciences, Tehran, Iran 2024 03 16 2024 03 16 Trigeminal neuralgia has an incidence of 4-13 per 100000 people per year. The incidence of this disease increases in the elderly, and it is known to cause severe shock-like pain. Pharmacological therapy is the first-line treatment of trigeminal neuralgia. If pharmacological therapy fails, then different procedures are available. Pulse-dose radiofrequency is one such procedure. In this study, we evaluated Pulse dose radiofrequency's efficacy as a method in which pulse amplitude and width are considered essential variables. This research was conducted as a cross-sectional study on trigeminal neuralgia patients referred to the pain clinic of Amir A’lam Hospital in 2020. Conservative therapy has failed; therefore, the clinician decided to use pulse dose radiofrequency to reduce their pain. Among the 29 patients registered during this period, 15 (51.8%) were women and 14 (48.3%) were men. The mean (±SD) age of the patient was 57.07(±14.26) years. The tow route was interrupted in 7 (24.1%) patients. A significant difference was observed between the pain scores before and after the operation (P<0.001). Pulse-dose radiofrequency is a safe and effective therapy for treating trigeminal neuralgia and can be considered a new way to develop the pulse radiofrequency method. https://acta.tums.ac.ir/index.php/acta/article/view/11022 https://acta.tums.ac.ir/index.php/acta/article/download/11022/5843