Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 33 1-2 1995 06 15 18 21 Ali Zare Mehrjardi Fereshteh Ensani 2015 09 28 Nucleolar organizer regions are loops a/nuclear DNA related to ribosomal DNA, and their number in cells is believed to indicate cellular proliferative activity. Using_a silver staining methodto visualize thesestructures inparaffin embeddedtissue sections, an attempt was made to determine ifthese AgNOR counts could be used as a diagnostic toolfor serous borderline tumors of the ovary. Ten cases in each group a/benign, borderlineand malignantserous ovarian tumorswereselectedand themean numberofAgNORwas determined in all cases. A progressive increase in mean AgNORvalues was naedfrom the benign l oup towards the borderlinegroup and further to the carcinomagrOUPi the differences between the means in. each gr~Uwere statistically significant However, there was a high ee of overlap between the values ofthe borderline and . ant groups. Theseresults indicatethat AgNORcountsmaynot be very useful as a diagnostic tool in an individual case. https://acta.tums.ac.ir/index.php/acta/article/view/1657 https://acta.tums.ac.ir/index.php/acta/article/download/1657/1650