Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 34 3-4 1996 12 15 95 100 Z. Safaii Naraghi. P. Mansouri M.R. Mortazavi 2015 09 28 Scleromyxedema is a rare, chronic, progressive, fibromucinous disorder of unknown etiology, characterized by lichenoid waxy papules and firm induration of skin of trunk, face, forearm and hands; fibroblast proliferation and mucin deposition in the upper dermis. Cutaneous involvement is characteristic but there are several associated systemic manifestations: We observed a case of scleromyxedema with multiple systemic manifestations including endocrinopathy and hypothyroidism. Scleromyxedema is a multisystem disorder associated with multiple organ involvement including liver, muscle, kidney and could be associated with endocrinopathies including hypothyroidism. https://acta.tums.ac.ir/index.php/acta/article/view/1704 https://acta.tums.ac.ir/index.php/acta/article/download/1704/1697