Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 37 1 1999 03 15 5 10 S. Makjoub M. Zakraei F. Karami2 M. A. Mohagheghi  h.zeraeti 2015 09 28 The P53 protein is expressed in all normal cells and appears to function in cell cycle regulation. Abnormally higli levels of the protein are found in many different types of cancer. In breast cancer, overexpression of P53 is associated with point mutations within highly conserved regions of the P53 gene. These altered genes encode stable P53 protein that can be detected by standard immunohistochemical techniques. In this study, we examined 47 cases of primary breast carcinoma for the presence of P53 protein using immunohistochemistry methods employing monoclonal antibody against the clone, DO-7. Of these specimens, 25.5% had widespread overexpression of P53. A significant positive correlation waz found between P53 overexpression andyounger age (P https://acta.tums.ac.ir/index.php/acta/article/view/1760 https://acta.tums.ac.ir/index.php/acta/article/download/1760/1753