Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 37 1 1999 03 15 63 67 P. Mansouri M. Lotfi M.R. Mortazavi Z. Safaii Naraghi 2015 09 28 Florid cutaneous papillomatosis (FCP), is a rare cutaneous marker of internal malignancy. The underlying cancer is usually intra-abdominal (most often gastric in origin), and evolves parallel to the FCP. There is a common association between FCP and the other two eruptive paraneoplastic syndromes, i.e.malignant acanthosis nigricans and the sign of Leser-Trelat. It seems possible that these syndromes develop via a common pathogenic pathway due to production of a factor similar to human epidermal growth factor by the underlying cancer. We report a case of FCP associated with malignant acanthosis nigricans, palmoplantar keratoderma and gastric adenocarcinoma. https://acta.tums.ac.ir/index.php/acta/article/view/1772 https://acta.tums.ac.ir/index.php/acta/article/download/1772/1765