Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 37 2 1999 06 15 68 72 Sh. Sadr  A. Nahavandi A.R. Mani  A.R. Dehpour 2015 09 28 In this study the effect of nitric oxide synthesis inhibition on stress-induced gastric damage was evaluated in bile duel ligated, sham operated and unoperated rats. Animals were injected intraperitoneally with NG-nitro-L-arginine methylester (L-NAME), 40 mglkg, L-argininc, 200 mg/kg or saline, 30 min before water-immersion stress. One hour after water immersion, the animals were killed and their stomachs were removed for measurement of gastric mucosal damage. Tfie results showed that L-NAME significantly enhances the development of gastric mucosal lesion in sham operated and unoperated rats, while in bile duct ligated animals, L-NAME decreases and L-arginine enhances the potentiation of stress-induced gastric mucosal damage. The results suggest that inhibition of nitric oxide synthase with L-NAME has different effects on stress-induced gastric damage in cholestatic rats compared with normal animals. https://acta.tums.ac.ir/index.php/acta/article/view/1773 https://acta.tums.ac.ir/index.php/acta/article/download/1773/1766