Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 31 1-4 1993 12 15 57 64 Massoumeh Ebtekar & Nematollah Khansari 2015 09 28 The close relationship between the immune system and the central nervous system (CNS) has been well-studied. The CNS regulates almost all the functions of the immune system; however, the effect and/or the control of the immune system on the CNS has not been well-studied yet. Recent reports suggest that the CNS has its own defence mechanism(s). In this review, attempts have been made to discuss some of the controversial issues in order to approach a clear conclusion. https://acta.tums.ac.ir/index.php/acta/article/view/226 https://acta.tums.ac.ir/index.php/acta/article/download/226/222