Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 32 1-2 1994 06 15 64 68 Ali Mahfouzi  Mohammad Reza Zarrindast 2015 09 28 1) Chronic administration of morphine hydrochloride in the drinking water of mice induced physical dependence. Jumping and diarrhea, two signs of withdrawal, were produced by intraperitoneal (IP) injection of naloxone. 2) Baclofen, bicuculline and picrotoxin decreased the number of mice's jumping episodes and frequency of diarrhea. 3) Muscimol decreased jumping but not diarrhea. 4) The data indicate that GABA-Ergic system is possibly involved in the morphine physical dependence, but further studies are required to elucidate the roles of GABA-A or GABA-B receptor sites in physical dependence. https://acta.tums.ac.ir/index.php/acta/article/view/240 https://acta.tums.ac.ir/index.php/acta/article/download/240/236