Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 40 3 2002 09 15 181 186 Sotoudeh G Siassi F Mirdamadi SR Mohammad K Golestan B Chamari M 2015 09 28 Hyperandrogenism affects 2-6% of all women. Hypertension is one of disturbances which is related to androgen excess. Higher intakes of vitamin C and vitamin E have been associated with lower blood pressure. Tho investigate the effect of these vitamin supplementation on blood pressure in hyperandrogenic women, a randomized, double-blind, placebo-controlled study was designed on 56 women 18-54 years old. Women were randomly allocated to one of four treatment groups: spironolactone plus vitamain C and viamin E (SCE), spironolactone plus vitamins placebo (SP), vitamin C plus vitamin E (CE), vitamins placebo (P). The treatment consisted of oral administration of 100 mg spironolactone, 1000 mg vitamin C and 900 mg vitamin E (alpha-tocopherol acetate) daily for about 3 months. Results indicated that compared to pretreatment, vitamins supplementation significantly lowered systolic (119.1±12.6 vs. 112.6±15.4 mmHg) and mean blood pressure (97.4±11.5 vs. 92. ±12.1 mmHg) SCE group (P https://acta.tums.ac.ir/index.php/acta/article/view/2606 https://acta.tums.ac.ir/index.php/acta/article/download/2606/2588