Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 43 4 2005 08 15 303 305 A. R. Taheri H. Abdali 2015 09 28 Warfarin induced skin necrosis is a rare complication associated with the use of oral ‎anticoagulants. Most patients develop this complication at the initiation of therapy. The complication is ‎usually associated with an underlying thrombophilia. Here we describe a case of a 75 year old ‎patient who developed skin necrosis in her both breasts during warfarin treatment for a ‎deep vein thrombosis. Thrombophilia screening demonstrated the presence of protein S and ‎antithrombin III deficiency. The necrotic lesion was excised and defects eventually ‎covered with skin flaps. https://acta.tums.ac.ir/index.php/acta/article/view/3014 https://acta.tums.ac.ir/index.php/acta/article/download/3014/2995