Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 43 6 2005 12 15 381 386 M. Ghabace M. Ghafarpoor K. Neurijeliani F. Vafaee K. Alikhani H. Sadeghian 2015 09 28 Chronic acquired demyelinating neuropathy (CADP) is heterogeneous ill both clinical and laboratory features. This study was performed to define the clinical. clccuodiagnostic and histological findings. course and response 10 therapy in patients with CADI'. Thirty patients (20 men and 10 women) with CADI' were studied. Diagnostic criteria were based on clinical presentation. clcctrophysiolcgical studies. cerebrospinal fluid (CSF) protein level and sural nerve biopsy findings. Response 10 treatment was assessed by changes in average muscle score (A:vlS). Twenty-one patients conformed to the diagnostic criteria of chronic inflammatory demyelinating polyneuropathy (Cf Dl") and 9 to distal acquired demyelinating symmetric neuropathy (DADS). The course was monophasic in Cl (23~/~-)), relapsing in I0 (40(~/;1) and chronic progressive in 8 (30':••;,): 4( 13°•'()) had ucutc presentation with subsequent progression or relapsing course. Motor nerve conduction velocity (i"--INCV) of less than 70°,-() and greater than 70'~;(, of normal were seen in 18 (60'~';)) and 12 (40{~-;1) patients. respectively. Conduction block was observed in 14 (47(~/o) and CSF protein levels WCl"C elevaled in 19 patients (66':--;)). Demyelination was reported in 61(;--() and 58%) of the biopsies performed in patients with MNCV https://acta.tums.ac.ir/index.php/acta/article/view/3029 https://acta.tums.ac.ir/index.php/acta/article/download/3029/3010