Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 44 5 2006 10 15 354 356 B. Jahangiri R. Jahangiri 2015 09 28 Intrathecal administration of midazolam has been reported to have antinociceptive action, and to be an effective analgesic agent. In this prospective double-blind study we aimed to evaluate the postoperative effects of intrathecal midazolam with lidocaine following perineal operation. Forty patients were randomly allocated to two groups: 20 patients in the control group received 2 ml of 5% heavy lidocaine plus 0.4 ml of 0.9% saline intrathecally; 20 patients in the midazolam group received 2 ml of 5% heavy lidocaine plus 0.4 ml of 0.5% midazolam. Duration of analgesia was significantly greater in the midazolam group (7  1 hours) compared to the control group (1.5  0.5 hours). https://acta.tums.ac.ir/index.php/acta/article/view/3214 https://acta.tums.ac.ir/index.php/acta/article/download/3214/3192