Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 45 1 2007 02 15 83 84 S. Al-Yasin S. H. Nabavizadeh M. Nabavi M. Kiani M. Safari O. Zekavat 2015 09 28 Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer representing 80-85% of all leukemia. We describe a 3 years old girl with pain, swelling and tenderness in extremities since 8 months prior to her present admission. X-ray of extremities revealed callus formation, osteopenia and site of healed fractures. Bone marrow aspiration revealed ALL-L2 with normal peripheral smear. It is important for physician to recognize the skeletal manifestations of acute leukemia of childhood because a delay in diagnosis has an adverse effect on survival. https://acta.tums.ac.ir/index.php/acta/article/view/3247 https://acta.tums.ac.ir/index.php/acta/article/download/3247/3225