Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 45 6 2007 12 15 481 486 A. Ghanei F. Esfananian A. Esteghamati J. Behjati S. Hamidi M. Nakhjavani 2015 09 28 Lecithin cholesterol acyltransferase (LCAT) plays a major role in the removal of free cholesterol from tissues via assisting HDL-C maturation, and its activity has been proposed as the main indicator of HDL-C function. The aim of the study was to measure LCAT activity in type 2 diabetic patients and to elucidate whether LCAT is associated with metabolic control, and insulin resistance. A case-control study was conducted in Imam Khomeini Hospital during 2006, recruiting 45 type 2 diabetes mellitus patients and 45 healthy subjects. Cases and controls were matched regarding gender, age and body mass index (BMI). FBS, lipid profile, LCAT activity, HbA1C, insulin were measured and insulin resistance (HOMA-IR)was calculated for both patients and controls. The studied variables were then compared between the two groups, and the association of LCAT activity with any of the variables was examined. Twenty-five subjects were female and 20 male both among patients and controls. Mean age of diabetics was 49.9 yrs (range, 40-64), and of controls 51.1 yrs (range, 39-64). FBS, HbA1C, HOMA-IR and TG in patients were significantly higher than controls, and HDL-C in controls was significantly higher than patients. LCAT activity of patients (73 9.1 µmol/L/h) was significantly lower than that in controls (88 4.5 µmol/L/h) (p https://acta.tums.ac.ir/index.php/acta/article/view/3322 https://acta.tums.ac.ir/index.php/acta/article/download/3322/3300