Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 46 1 2008 02 15 84 86 A. Ramyar B. Yaghmaie M. Monajemzadeh 2015 09 28 Langerhans cell histiocytosis (LCH) is the most common type of childhood histiocytic disorder with an incidence of 0.2 to 1 per 100,000 children under the age of 15 years (1). The clinical picture of LCH varies from single system (S-S)bone or skin disease to multi-system disease (M-S) (2). We report a neonate with disseminated papulonodular eruption containing mononuclear CD1a and S100 positive histiocytic cells infiltration at epidermis and underlying dermis. The diagnosis of a congenital self healing Langerhans cell histiocytosis (CSHLCH) was made and follow up showed a complete recovery of the eruptions , leaving hypopigmented macules in the sites corresponding to the initial findings. https://acta.tums.ac.ir/index.php/acta/article/view/3448 https://acta.tums.ac.ir/index.php/acta/article/download/3448/3425