Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 46 6 2008 12 15 507 510 F Davatchi Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me F Shahram Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me A Nadji Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me S Soroosh Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me A Jamshidi Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me C Chams Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me H Chams Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me M Akbarian Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me F Gharibdoost Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me M Akhlaghi Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me B Sadeghi-Abdollahi Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me N Ziaie Department of Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University of Me 2015 09 28 There is some data in the literature on the association of HLA-B5 and some manifestations of Behçet's disease (BD), especially ocular lesions. We studied 433 patients to see if there was any relationship between B51 and the manifestations of the disease. Clinical manifestations of BD were compared in patients having HLA-B51 (155 patients) and those lacking HLA-B51 (278 patients). Oral aphthosis, genital aphthosis, skin manifestations, joint manifestations, gastrointestinal manifestations, phlebitis and neurological manifestations showed no significant difference in patients with and without HLA-B51. Ophthalmologic manifestations were seen in 52% of patients having B51 and in 42% of patients lacking it (χ2: 4.451, P = 0.035). Considering different lesions of ocular manifestations separately, no significant difference was found regarding the presence or absence of B51. Pathergy phenomenon was detected in 55% of B51 positive patients and in 45% of B51 negative patients (χ2: 4.111, P = 0.043). It seems that HLA-B51 may play a role in the pathogenesis of Behçet's disease, but cannot be used as predictive value for the occurrence of organ involvement, except for the eye. https://acta.tums.ac.ir/index.php/acta/article/view/3529 https://acta.tums.ac.ir/index.php/acta/article/download/3529/3505