Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 46 6 2008 12 15 518 520 M Ghafari Department of Anesthesiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Ira M Akrami Department of Anesthesiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Ira M Sadeghi Department of Anesthesiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Ira M Ghoreishinejad Department of Anesthesiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Ira 2015 09 28 Toxic reactions to local anesthetics may occur due to over dose, accidental intravenous injections or rapid systemic uptake of the drugs. But there have been few reports on toxicity due to displacement of epidural catheters after an initial correct insertion and performance of a test dose.  Here we present a case of local anesthetics toxicity due to possible displacement of the epidural catheter during APR (Ant-post Colporrhaphy) surgery. The patient's level of consciousness decreased at the end of surgery. She demonstrated CNS and cardiovascular toxicity due to local anesthetics. Consequently the patient was intubated and transferred to ICU, where she received mechanical ventilation along with other supportive treatments such as inotropic and antiepileptic drugs. We concluded that supportive therapy is the treatment of choice for such cases. https://acta.tums.ac.ir/index.php/acta/article/view/3531 https://acta.tums.ac.ir/index.php/acta/article/download/3531/3507