Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 47 1 2009 02 15 65 70 EN Mehdi Farzadnia Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Hossein Ayatollahi Department of Hematopathology and Blood banking; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Maliheh Hasan zade Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Hadi Sadeghian Department of Hematopathology and Blood banking; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Naser Tayebi Meybodi Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2015 09 28 Endothelial dysfunction is thought to be a central pathogenic feature in pre-eclampsia on the basis of elevated adhesion molecules. Soluble forms of these molecules can be detected in plasma, and their concentrations are thought to reflect the degree of activation of a particular cell type. The aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) in sera of normal and pre-eclamptic pregnancies. A cross-sectional study was conducted to determine the plasma concentrations of sVCAM-1 in peripheral blood obtained from normal pregnant women (n=40), mild pre-eclampsia (n=37) and severe pre-eclampsia (n=38). Concentrations of soluble adhesion molecule was determined with enzymelinked immunosorbant assay (ELISA). Serum concentration of sVCAM-1 was significantly higher in severe preeclampsia (P<0.05) than normal pregnancy. There was also significant differences in sVCAM- 1 levels between mild and severe pre-eclampsia (P<0.05). There was no difference in the mean plasma log sVCAM1between normal pregnant women and mild pre-eclamptic women. These results suggest soluble vascular cell adhesion molecule-1 are increased in severe pre-eclampsia, and sVCAM-1may be useful in predicting the severity of pre-eclampsia. https://acta.tums.ac.ir/index.php/acta/article/view/3546 https://acta.tums.ac.ir/index.php/acta/article/download/3546/3522