Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 47 1 2009 02 15 81 82 EN Ahmad Hashemzadeh Department of Pediatrics, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Farhad Heydarian Department of Pediatrics, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2015 09 28 It is an autosomal recessive, and occasionally autosomal dominant mutant extremely rare disorder with only 100 reported case in literature. This fatal disorder occur in both sexes and all races. In most circumstances the newborn die soon after birth Also it is known as harlequin fetus, alligator baby or keratosis diffusa fatalis. Because of its rarity, we report 2 cases of this disorder, here. https://acta.tums.ac.ir/index.php/acta/article/view/3550 https://acta.tums.ac.ir/index.php/acta/article/download/3550/3526