Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 48 1 2010 02 15 72 74 EN Kamran Balighi Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Khalil Farsinejad Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohamadreza Barzegar Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Zahra Naraghi Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Seyed Mohammad Ali Mortazavizadeh Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 09 28 We present a case of epitheloid sarcoma that was referred with a 2×3cm ulcerated lesion on the right ankle and edema of the lower leg. Foot drop of the right side was present that had caused walking difficulty. After a few months, he developed several sporthricoidal nodular lesions on the medial aspect of right thigh, inguinal lymphadenopathy, weight loss, anorexia and respiratory symptoms. Chest x-ray and HRCT showed pulmonary metastasis. Histopathological evaluation and immunohistochemical profile of both skin lesion and involved inguinal lymph node were consistent with epitheloid sarcoma. The case is interesting because as far as we know there has been no report of epitheloid sarcoma in literature presenting with foot drop and edema prior to obvious skin involvement. https://acta.tums.ac.ir/index.php/acta/article/view/3651 https://acta.tums.ac.ir/index.php/acta/article/download/3651/3626