Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 48 2 2010 04 15 123 124 EN Saeid Morowati Research Center for Human Genetics, Baqiyatallah University of Medical Sciences, Tehran, Iran. Mobin Yasini2 Research Center of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran. Reza Ranjbar Research Center of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran. Ali Asghar Peivandi Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohsen Ghadami Medical Genetics Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 09 28 Ankyloglossia (tongue-tie) is a congenital anomaly with a prevalence of 4-5% and characterized by an abnormally short lingual frenulum. For unknown reasons the abnormality seems to be more common in males. The pathogenesis of ankyloglossia is not known. The authors report a family with isolated ankyloglossia inherited as an autosomal dominant or recessive trait. The identification of the defective gene(s) in these patients might reveal novel information on the pathogenesis of this disorder. https://acta.tums.ac.ir/index.php/acta/article/view/3662 https://acta.tums.ac.ir/index.php/acta/article/download/3662/3637