Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 48 3 2010 06 15 133 141 Kianoush Khosravi-Darani National Nutrition and Food Technology Research Institute, Shahid Beheshti Medical University, Tehran, Iran. Mohamaad Reza Mozafari Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia. Ladan Rashidi Department of Food & Agriculture Research, Institute of Standard and Industrial Research of Iran, Karaj, Iran. Mehrdad Mohammadi National Nutrition and Food Technology Research Institute, Shahid Beheshti Medical University, Tehran, Iran. 2015 09 28 Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and nonviral vectors, were found to have a positive effect on gene transfer especially when incorporated in the colloidal particulate systems. This review elaborates on various successful methods of using calcium phosphate nanoparticles in gene delivery, which are considered an advancing approach to gene delivery. https://acta.tums.ac.ir/index.php/acta/article/view/3666 https://acta.tums.ac.ir/index.php/acta/article/download/3666/3641