Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 49 1 2011 01 15 64 69 EN Seyed Ali Ahmadi Department of pathology, Sina Hospital, Tehran University of Medical Sciences; Tehran, Iran. Hadi Roozbeh Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences; Tehran, Iran. Ali Abbasi Department of Pathology, Sina Hospital, Tehran University of Medical Sciences; Tehran, Iran. Moslem Bahadori Department of Pathology, Sina Hospital, Tehran University of Medical Sciences; Tehran, Iran. Katayoun Gohari Moghaddam Department of Pathology, 501 Hospital, Army University of Medical Sciences; Tehran, Iran. Seyed Ebrahim Ketabchi Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences; Tehran, Iran. 2015 09 28 Tubercle bacilli infect about one third of the world's population and over the past decade resurgence of tuberculosis has been a major health threat mainly due to increasing frequencies of immunosuppressive states and drug-resistant organisms. Although tuberculosis is essentially a lung disease, intracranial elements become involved in 5-10% of cases either as meningitis or tumour-like masses (tuberculoma). Tuberculoma is common in endemic areas but its occurrence during pregnancy is occasional and of particular interest is its intriguing clinical picture mimicking toxemia of pregnancy and brain tumor. In addition, the effects of pregnancy on tuberculosis or vice versa have been controversial. We present here a review of the recent literature and discuss a case coming to medical attention with manifestations of intracranial hypertension during 2 consecutive pregnancies; 4 years apart. On operation a dura-attached mass was detected that proved to be a tuberculoma. After 18 months of close observation and under drug therapy she obviously improved with no ensuing complication. Immunodeficiency state associated with pregnancy is likely to play a role in activation of infection. Tuberculoma should be considered in differential diagnosis of eclampsia and brain mass particularly in women coming from endemic areas for this infection even in the absence of pulmonary involvement. https://acta.tums.ac.ir/index.php/acta/article/view/3694 https://acta.tums.ac.ir/index.php/acta/article/download/3694/3669