Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 49 2 2011 02 15 81 84 EN Laleh Eslamian Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Fariba Behnam Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Zahra Foroohesh Tehrani Department of Clinical laboratory and Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ashraf Jamal Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Vajiheh Marsoosi Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 09 28 To evaluate the value of random urinary protein creatinine ratio in prediction of 24h proteinuria in hypertensive pregnancies. Method: Random urine samples and routine 24h urine collections were collected from hypertensive pregnant women (n=100). Reliability of random urinary protein–creatinine ratio was assessed by receiver operator characteristic (ROC) curve to detect significant proteinuria (300mg/day) using 24h. Urine protein as a gold standard. Forty six patients (46%) had significant proteinuria. The random protein creatinine ratio was correlated to 24h urine protein excretion (r2 =0.777, P<0.001) Area under ROC curve to predict proteinuria was 0.926 (95% CI: 0.854–0.995, P<0.001). A cut off value of 0.22mg/mg for protein creatinine ratio best predicted significant proteinuria with sensitivity, specificity, positive and negative predictive values of 87%, 92.6%, 90.6% and 89.3% respectively. Random urinary protein creatinine ratio is a simple inexpensive and excellent alternative to 24h urine collection. It's helpful in diagnosis of preeclampsia and can be used as a pre admission test in PIH cases. https://acta.tums.ac.ir/index.php/acta/article/view/3697 https://acta.tums.ac.ir/index.php/acta/article/download/3697/3672