Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 49 2 2011 02 15 118 121 EN Mohammad Sadeghi Hasanabadi Otorhinolaryngology Research Centre, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mandana Amiri Otorhinolaryngology Research Centre, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ardavan Tajedini Otorhinolaryngology Research Centre, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Alireza Karimi Yazdi Otorhinolaryngology Research Centre, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mona Heidarali Otorhinolaryngology Research Centre, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Amin Amali Otorhinolaryngology Research Centre, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Banazadeh Departments of Thoracic Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Zahra Mokhtari Otorhinolaryngology Research Centre, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Azizi Department of Pathology, Shahriar Hospital, Tehran, Iran. 2015 09 28 Although esophageal liposarcoma is an extremely rare tumor, liposarcoma is the most common soft tissue sarcoma in adults. Liposarcoma is currently classified into the types of well-differentiated, myxoid, round cell, pleomorphic and dedifferentiated liposarcoma. Up to now only a few cases of esophagus liposarcoma have been described in the world literature. We describe a myxoid type liposarcoma of the esophagus in a 68 year old man presented with hoarseness and intermittent dysphagea to solid food. He had a huge mass in his mouth which was mobile with gag reflex. A barium swallow, esophageal manometery and CT scan of the esophagus have not clearly revealed the mass. After endoscopic surgical resection of the tumor the histological examination revealed a myxoid liposarcoma. Both the presenting signs and symptoms and the histology type are rare for such tumor. This case demonstrate a rare differential diagnosis of intermittent dysphagia as early diagnosis is so important in those tumors and should kept in mind them, although they are quite rare. https://acta.tums.ac.ir/index.php/acta/article/view/3706 https://acta.tums.ac.ir/index.php/acta/article/download/3706/3681