Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 49 11 2011 11 15 763 765 EN Hossain Jabbari Infectious Diseases Department, Tehran University of Medical Sciences, Tehran, Iran. AND Digestive Diseases Research Institute (DDRI), Tehran University of Medical Sciences, Tehran, Iran. AND Iranain Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Payvarmehr Iranain Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran. SeyedAhmad SeyedAlinaghi Iranain Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran. Neda Roosta Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 2015 09 28 We present a 24-year-old female referred with non-healing wound of a few days duration on anterior aspect of her right foreleg. Biopsy of the wound was reported to be pyoderma gangrenosum on pathologic report. Further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia. Treatment with granulocyte colony-stimulating factor (G-CSF) resulted in patient's neutrophil counts correction and dramatic improvement in healing of her lower extremity wound. https://acta.tums.ac.ir/index.php/acta/article/view/3834 https://acta.tums.ac.ir/index.php/acta/article/download/3834/3809