Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 50 8 2012 08 15 535 540 EN Hossein Ghanaati Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Medical Imaging Center, Imam Khomeini Hospital, Tehran University of medical Sciences, Tehran, Iran. Vahid Mohammadzadeh Medical Student, Tehran University of Medical Sciences, Tehran, Iran. Ali Mohammadzadeh Department of Radiology, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical sciences, Tehran, Iran. Kavous Firouznia Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Medical Imaging Center, Imam Khomeini Hospital, Tehran University of medical Sciences, Tehran, Iran. Maryam Mohammadzadeh Department of Radiology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Marzieh Marzieh Motevali Department of Radiology, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical sciences, Tehran, Iran. Sakineh Kadivar Department of Ophthalmology, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht, Iran. Mohammad Ali Mohammadzadeh Department of Vascular Surgery, Poursina Hospital,Guilan University of Medical Sciences, Rasht, Iran. Abbas Dargahi Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Medical Imaging Center, Imam Khomeini Hospital, Tehran University of medical Sciences, Tehran, Iran. Amir Hossein Jalali Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Medical Imaging Center, Imam Khomeini Hospital, Tehran University of medical Sciences, Tehran, Iran. Madjid Shakiba Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Medical Imaging Center, Imam Khomeini Hospital, Tehran University of medical Sciences, Tehran, Iran. Payam Azadeh Department of Radiotherapy and Oncology, Jorjini Cancer Center, Imam Hossien Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2015 09 28 Following failure of systemic chemotherapy, transarterial chemoembolization (TACE) is an available method to control unresectable liver metastases from colorectal carcinoma (CRC). The aim of present study was to evaluate the efficacy of chemoembolization for inoperable metastatic liver lesions from CRC. Forty-five CRC patients with liver metastases resistant to systemic chemotherapy were enrolled in our study. For each patient, three session of TACE were conducted with 45 days interval. A combination of mitomycin, doxorubicin, and lipiodol were used for TACE. A tri-phasic computed tomography scan and biochemical laboratory tests were performed for all patients at baseline and 30 days after each TACE. Image analysis included measurement of lesion diameters as well as contrast enhancement. Eleven patients deceased before completing three session and the final analyses were performed on the remaining 34 patients. Evaluation of a total 93 lesions in all patients after chemoembolization sessions revealed a 25.88% reduction in anteroposterior (AP) diameter, 33.92% transverse (T) diameter, and 42.22% in product of APxT diameter of lesions (P<0.001 for all instances). CT scan showed a total disappearance of 33% of lesions and evident reduction in contrast enhancement in 16% of them. There were no changes in contrast enhancement in 51% of lesions. Evaluation of single largest lesion in each patient revealed 57.32% reduction in AP diameter, 59.66% in T diameter, and 62.17% in product of APxT diameters (P<0.001 for all diameters). TACE offers a viable option for CRC patients with unresectable liver metastases by significantly reducing lesion size and contrast enhancement. https://acta.tums.ac.ir/index.php/acta/article/view/3944 https://acta.tums.ac.ir/index.php/acta/article/download/3944/3919