Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 9 2013 09 15 655 656 EN Fatemeh Farahmand Department of Pediatric Gastroenterology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Khadije Soleimani Department of Cardiology, Arak University of Medical Sciences, Arak, Iran. Mojtaba Hashemi Department of Cardiology, Arak University of Medical Sciences, Arak, Iran. Arezoo Shafieyoun Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Nima Rezaei Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Azizollah Yousefi Department of Pediatric Gastroenterology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Congenital hepatic fibrosis (CHF) is a developmental disorder of the biliary system, characterized by defective remodeling of the ductal plate. Herein a family of three children, from consanguineous parents, with minor thalassemia is presented who suffered from congenital hepatic fibrosis (CHF). Prompt diagnosis and appropriate treatment are necessary to avoid further complications in the affected patients. https://acta.tums.ac.ir/index.php/acta/article/view/4358 https://acta.tums.ac.ir/index.php/acta/article/download/4358/4392