Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 8 2013 08 15 572 576 EN Masoud Poureisa Neurosciences Research Center, Department of Radiology, Radiotherapy and Nuclear Medicine, Tabriz Medical Science University, Tabriz, Iran. Mohammad Hossein Daghighi Department of Radiology, Radiotherapy and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Ramin Mazaheri-Khameneh Department of Clinical Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Ali Ghadirpour Department of Radiology, Radiotherapy and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. 2015 10 11 We present 16 years old girl with primary breast lymphoma involving the both breasts simultaneously and co-incidence of central nervous system (CNS) involvement which originated from the breast, in addition to evidence of lymphoma in multi-organ such as skin, mediastinum and some abdominal viscera. Bilaterality has been observed in some series, but reports are few and series are often very small. Radiologic features may be indistinguishable from those of the other breast malignancies, but it can be concluded that primary involvement of the breast with lymphoma should be considered when breast mass or inflammatory changes occur in a patient without any previously diagnosed lymphoma. The clinical behavior, imaging and therapeutic procedures are discussed. The findings of this report may have clinical impact on oncologists or that may alter the disease concept of bilateral breast lymphoma. https://acta.tums.ac.ir/index.php/acta/article/view/4390 https://acta.tums.ac.ir/index.php/acta/article/download/4390/4299