Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 5 2013 05 15 314 319 EN Mohammad Najafi Department of Biochemistry, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Behnam Alipoor Department of Biochemistry, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. 2015 10 11 Oxidized LDL (ox-LDL) lipoproteins are proposed as important modified particles triggering pro-inflammatory events through receptor-mediated pathways. We evaluated the circulating ox-LDL level on the concept that the chronic immune events may affect ox-LDL clearance as the vessel stenosis develops in coronary arteries. One hundred sixty five subjects underwent coronary angiography and then, subdivided into four subgroups controls (n=85); SVD, 2VD and 3VD (n=80). The serum ox-LDL level and other biochemical parameters were measured using ELISA method and routine laboratory techniques, respectively. The serum ox-LDL level in the control group (4.81±1.41 mU/mg) was significantly higher than patients (4.28±1.73 mU/mg, P<0.05). The ox-LDL/LDL ratio was conversely reduced with the extent of stenosis as compared with the controls (P<0.05). Furthermore, no difference was observed in the ox-LDL/LDL ratio between the 2VD and 3VD patients. We suggested the atherosclerosis process increases the total clearing capacities of the circulating ox-LDL particles. https://acta.tums.ac.ir/index.php/acta/article/view/4440 https://acta.tums.ac.ir/index.php/acta/article/download/4440/4588