Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 51 3 2013 03 15 157 162 EN Farshid Arbabi-Kalati Brain and Spinal Injury Research Center, Tehran Universityof Medical Sciences, Tehran, Iran. Fatemeh Arbabi-Kalati Department of Oral Medicine ,Genetic of Non Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Tahora Moridi Zahedan University of Medical Sciences, Zahedan, Iran. 2015 10 11 Radiotherapy in the head and neck region and chemotherapy might give rise to oral mucositis which is a severe and painful inflammation. There is no known definite cure for mucositis. A number of studies have attempted to evaluate the effect of low-power laser on radiotherapy- and chemotherapy-induced mucositis. The present study was undertaken to evaluate the effect of low-power laser on the prevention of mucositis, xerostomia and pain as a result of chemotherapy. The subjects in this double-blind randomized controlled study were 24 adult patients who underwent chemotherapy during 2009-2010. The results showed that low-power laser was able to decrease the effect of chemotherapy on oral mucositis, xerostomia and pain in a variety of malignancies (P<0.05). It can be concluded that low-power laser might decrease the intensity of mucositis. https://acta.tums.ac.ir/index.php/acta/article/view/4471 https://acta.tums.ac.ir/index.php/acta/article/download/4471/4421