Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 11 2014 11 15 811 815 EN Amira Hamzaoui Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. Rim Klii Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. Olfa Harzallah Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. Touhami Mahjoub Department of Internal Medicine, Fattouma Bourguiba Hospital, Monastir, Tunisia. Silvia Mahjoub Department of Genetic, University of Pharmacology, Monastir, Tunisia. 2015 10 11 To assess the association between polymorphisms of the IL-6 -174 G/C and Behçet's disease (BD) in Tunisian patients. DNA was extracted from blood samples taken from 43 Tunisian patients and 43 healthy controls. The polymorphisms were analyzed by PCR with the PCR-RFLP. No significant association was found between patients and controls concerning polymorphism of IL6 -174 G/C between the (allelic frequency: C (17.44 vs 8, 13%; P=0.17) et G (82,55 vs 91,86%; P= 0.21). Neither age of onset of BD nor sex appears to be influenced by allelic variation of SNP-174 G / C of IL6. Disease duration of BD was longer in patients having the form 174 G-allele. SNP -174G/C was more frequent in patients without significant association (32.5 vs 16,26% ; P=0.07). SNP -174 G/C was not associated with the HLA B51. Neither age of onset of BD nor sex appears to be influenced by SNP-174 G / C of IL6. Disease duration of BD was longer in the absence of the SNP-174 G/C IL6, with no significant difference (79.2 + / -45.095 vs.70.28 + / - 47.034 months, P=0.59). The polymorphism of IL6 -174 G/C does not modulate clinical expression of BD. The single nucleotide polymorphisms of the IL-6 do not appear to be associated with BD reconstruction. https://acta.tums.ac.ir/index.php/acta/article/view/4542 https://acta.tums.ac.ir/index.php/acta/article/download/4542/4654