Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 7 2014 07 15 569 74 EN Iraj Nazari Department of Vascular Surgery, Faculty of Medicine, Ahvaz Jondi-Shapour University of Medical Sciences, Ahvaz, Iran. Maryam H. Esfehani Department of Surgery, Faculty of Medicine, Ahvaz Jondi-Shapour University of Medical Sciences, Ahvaz, Iran. Mohsen Nouri Department of Neurosurgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ahmad R. Naeemi Department of Vascular Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Javad Salimi Department of Vascular Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mohammad R. Zafarghandi Department of Vascular Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 This study describes two cases of cervical sympathetic schwannoma operated at department of vascular surgery and review the literature to clarify the demographic, diagnostic, and therapeutic features of these rare lesions for the first time. Two 32- and 59-year-old ladies both presenting with a painless cervical mass were referred to our service with the initial diagnosis of carotid body tumor. At the operation, mobile masses which could be easily dissected from the surrounding arteries and veins, except for the cervical sympathetic trunk were observed. Micro-surgical techniques helped us with removing the lesions with saving the sympathetic trunk in both cases. No permanent deficits were observed post-operatively in patients. Angiographic studies can provide the only pre-operative clues to diagnose a sympathetic schwannoma. Total removal of the lesion at the expense of sacrificing the sympathetic nerve is associated with minimal neurologic deficits which are well tolerated by the patient. https://acta.tums.ac.ir/index.php/acta/article/view/4573 https://acta.tums.ac.ir/index.php/acta/article/download/4573/4517