Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 52 4 2014 04 15 315 318 EN Mahsa Ghajarzadeh Department of Neurology, Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. Rozita Jalilian Department of Neurology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Mohammadifar Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Tehran Iran. Mohammad Ali Sahraian Department of Neurology, MS Research Center, Sina Hospital, Tehran, Iran. Amirreza Azimi Department of Neurology, Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 11 Multiple sclerosis (MS) is an inflammatory disease of central nervous system (CNS) and sexual dysfunction (SD) is one of the most common disabilities of MS women. The aim of this study was to determine sexual function of women with MS (multiple sclerosis). One hundred definite MS patients MS patients and fifty age-matched healthy controls were enrolled. Demographic data (sex, age), duration of the disease and disease pattern extracted from patient's  files and Kurtzke Expanded Disability Status Scale (EDSS) recorded for each patient by an expert neurologist. Participants were asked to answer the valid and reliable Persian version of Beck depression inventory (BDI) and Female Sexual Function Index (FSFI) questionnaires. The total FSFI score and subscale scores differed significantly between the MS patients and the controls. There was a significant negative correlation between EDSS and FSFI scores (rho=-0.44, P<0.001) and significant positive correlation between EDSS and BDI (rho=0.36, P<0.001) in patients. Mean BDI and all subscales of FSFI differed significantly between patients with total FSFI score higher and lower than 26.55. Sexual dysfunction should be considered in women with multiple sclerosis. https://acta.tums.ac.ir/index.php/acta/article/view/4636 https://acta.tums.ac.ir/index.php/acta/article/download/4636/4385