Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 55 1 2017 02 05 6 23 EN Aligholi Sobhani Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Neda Khanlarkhani Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Maryam Baazm Department of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Farzaneh Mohammadzadeh Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Atefeh Najafi Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Shayesteh Mehdinejadiani Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Fereydoon Sargolzaei Aval Department of Anatomy, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 2015 10 13 2016 09 26 Stem cells are self-renewing and undifferentiated cell types that can be differentiate into functional cells. Stem cells can be classified into two main types based on their source of origin: Embryonic and Adult stem cells. Stem cells also classified based on the range of differentiation potentials into Totipotent, Pluripotent, Multipotent, and Unipotent. Multipotent stem cells have the ability to differentiate into all cell types within one particular lineage. There are plentiful advantages and usages for multipotent stem cells. Multipotent Stem cells act as a significant key in procedure of development, tissue repair, and protection. Multipotent Stem cells have been applying in treatment of different disorders such as spinal cord injury, bone fracture, autoimmune diseases, rheumatoid arthritis, hematopoietic defects, and fertility preservation. https://acta.tums.ac.ir/index.php/acta/article/view/4962 https://acta.tums.ac.ir/index.php/acta/article/download/4962/4885