Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 55 4 2017 05 16 272 276 EN Anju Bansal Department of Pathology, National Institute of Pathology (ICMR), Safdarjang Hospital Campus, New Delhi, India. Manveen Kaur Department of Pathology, National Institute of Pathology (ICMR), Safdarjang Hospital Campus, New Delhi, India. Varsha Dalal Department of Pathology, National Institute of Pathology (ICMR), Safdarjang Hospital Campus, New Delhi, India. 2015 10 13 2016 05 01 Sarcomas account for less than 1% of all primary breast malignancies, pleomorphic sarcoma of the breast being even rarer. We present two cases of pleomorphic sarcoma of the breast in a 35-year-old and a 43-year-old female. An extensive review of the available literature with evaluation of the etiology, changing terminologies and histopathologic features of pleomorphic sarcoma of the breast are discussed. The prognostic factors and treatment modalities have also been reviewed. https://acta.tums.ac.ir/index.php/acta/article/view/4970 https://acta.tums.ac.ir/index.php/acta/article/download/4970/4929