Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 4 2016 05 10 261 269 EN Seyed Hesameddin Abbasi Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Seyed Ebrahim Kassaian Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Saeed Sadeghian Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Abbasali Karimi Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Soheil Saadat Sina Trauma Research Center, Tehran University of Medical Sciences, Tehran, Iran. Flora Peyvandi Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Milan, Italy. AND Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. Arash Jalali Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Tahereh Davarpasand Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Shahin Akhondzadeh Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran. Nazila Shahmansouri Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Ali Boroumand Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Masoumeh Lotfi-Tokaldany Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Maryam Amiri Abchouyeh Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Farah Ayatollahzade Isfahani Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Frits Rosendaal Department of Clinical Epidemiology and Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands. 2015 10 17 2015 10 28 Anxiety may negatively affect the course of coronary artery disease (CAD). The aim of this study was to assess which factors are associated with anxiety in young adults with CAD. A cohort of individuals with premature coronary artery disease was formed between 2004-2011, as the Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (THC-PAC) study. Patients (men≤45-year-old, and women≤55-year-old) were visited between March 2013 and February 2014. All participants were examined, and their demographic, clinical, and laboratory data were collected. Then, all participants filled in the Beck Anxiety Inventory. Logistic regression models were used to identifying factors related to anxiety in both sexes. During the study, 708 patients (mean [SD] age: 45.3 [5.8] y, men:48.2%) were visited. Anxiety was present in 53.0% of participants (66.0% of women and 39.0% of men). The logistic regressions model showed that the associated factors for anxiety in men were opium usage (OR=1.89, 95% CI: 1.09-3.27), positive family history (OR=1.49, 95% CI:0.94-2.35), and creatinine serum level (OR=1.17, 95% CI:1.05-1.303); and in women were major adverse cardiac events (MACE) during follow-up (OR=2.30, 95% CI:1.25-4.23), hypertension (OR=1.71, 95% CI:1.07-2.73) and the duration of CAD (OR=0.99, 95% CI:0.98-1.00). In premature CAD patients, the determinants of anxiety seem to be different in each sex. Opium usage, positive family history of CAD, and creatinine serum levels in men, and MACE, hypertension, and duration of CAD in women appear the relevant factors in this regard. https://acta.tums.ac.ir/index.php/acta/article/view/4984 https://acta.tums.ac.ir/index.php/acta/article/download/4984/4784