Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 1 2016 02 01 76 78 EN Manouchehr Hekmat Department of Cardiovascular Surgery, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hamid Ghaderi Department of Cardiovascular Surgery, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mahnoosh Foroughi Department of Cardiovascular Surgery, Cardiovascular Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. S. Adeleh Mirjafari Brain and Spinal Injury Research Center (BASIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2016 01 20 Guillain-Barre syndrome is a neurologic disorder that may appear after infection or major surgery.  Guillian-Barre syndrome following cardiac surgery is rare and only based on case reports, and we review all of the published cases. A 52-year-old man after 5 months suffering from chest pain was referred to our hospital and underwent coronary artery bypass graft for 3 vessel disease. The patient was discharged without complication on the 5th postoperative day. He presented Guillain- Barre syndrome after 12 months. He has not completely recovered weakness of upper extremities grade 4/5 with atrophy of both upper extremities remains after 18 months. This disorder is similar to classic GBS. It is important to be alert to de novo autoimmune neurological disorders after cardiac surgery. These disorders are similar to classic autoimmune disease and treated with standard therapies. https://acta.tums.ac.ir/index.php/acta/article/view/5393 https://acta.tums.ac.ir/index.php/acta/article/download/5393/4742