Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 54 10 2016 11 19 657 661 EN Gholamreza Pouryaghoub Occupational Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. Ramin Mehrdad Department of Occupational Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Alireza Valipouri Department of Occupational Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2016 04 16 2016 06 06 Cardiovascular adverse effects are interesting aspects of occupational noise exposure. One possible mechanism of these effects is an alternation in hypothalamic-pituitary-adrenal axis. Our aim was to measure salivary cortisol response to relatively high-intensity noise exposure in a controlled randomized trial study. We exposed 50 male volunteers to 90 dBA noise for 20 minutes and compared their level of salivary cortisol with 50 non-exposed controls. Salivary samples obtained before and after exposure. Before intervention means (SD) salivary cortisol level were 3.24 (0.47)ng/ml and 3.25 (0.41)ng/ml for exposed and non-exposed groups respectively. Mean salivary cortisol level increased to 4.17 ng/mlafter intervention in exposure group. This increment was statistically significant (P=0.00). Mean salivary cortisol level of the non-exposed group had statistically non-significant decrement after this period (0.2 ng/ml). The difference between salivary cortisol level of non-exposed and exposed groups after the intervention was statistically significant. Noise exposure may affect the hypothalamic-pituitary-adrenal axis activity, and this may be one of the mechanisms of noise exposure cardiovascular effects. https://acta.tums.ac.ir/index.php/acta/article/view/5582 https://acta.tums.ac.ir/index.php/acta/article/download/5582/4850