Tehran University of Medical Sciences Acta Medica Iranica 0044-6025 56 2 2018 02 17 132 136 EN Seyed Hossein Fattahi Masoum Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Azadeh Jabbari Nooghabi Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Reza Rezaei Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2016 05 17 2016 12 31 Castleman’s disease (CD) is a rare benign lymphoproliferative disorder with unknown etiology and pathogenesis. It presents in two identified clinical forms of unicentric or multicentric. The disease is usually found incidentally in the mediastinal or hilar region in asymptomatic patients. In unicentric CD, constitutional symptoms are uncommon, and they can be misdiagnosed as lung infections or malignancy. Although imaging studies are helpful, but definitive diagnosis can be made with pathologic examination. Complete surgical resection is the method of choice for treatment of localized CD, and the prognosis is excellent. In this study, we elucidate clinical features and therapeutic consequences of four cases of unicentric CD referred to our department and review the literature on the diagnosis and management of this relatively rare disorder. Because of the rarity of the disease and nonspecific signs and symptoms of CD it must be considered in differential diagnosis of pulmonary and mediastinal masses. https://acta.tums.ac.ir/index.php/acta/article/view/5640 https://acta.tums.ac.ir/index.php/acta/article/download/5640/5058